Poorly Soluble Drugs with Low Bioavailability
Cov tshuaj uas tsis muaj dej solubility muaj teeb meem tseem ceeb hauv kev tsim, feem ntau ua rau qhov pib qeeb thiab tsis muaj qhov ncauj bioavailability. Yav dhau los, cov teeb meem no feem ntau tau hais los ntawm encapsulating cov tshuaj hauv cov tshuaj ntsiav lossis micronizing lawv. Tam sim no, kua- ntim tshuab capsule tso cai rau kev tsim cov kev daws teeb meem, tshem tawm, microemulsions, lossis cov ntsiab lus molten siv cov kuab tshuaj tsim nyog lossis cov nqa khoom. Piv txwv li, digoxin thiab cyclosporine tuaj yeem tsim tau rau hauv cov roj daws, thiab nifedipine rau hauv PEG (polyethylene glycol) 6000 melts, uas tom qab ntawd muab ntim rau hauv cov kua - puv capsules siv cov cuab yeej tshwj xeeb, yooj yim daws cov teeb meem nqus.
Tsawg-Melting-Point Tshuaj
Cov tshuaj uas muaj cov ntsiab lus melting tsawg los yog cov kua hauv chav tsev yog qhov nyuaj rau kev tsim cov hmoov nplej, feem ntau yuav tsum tau ntxiv cov khoom siv ntxiv. Qhov kub thiab txias thaum lub sij hawm tsim cov ntsiav tshuaj kuj cuam tshuam cov tebchaw uas tsis tshua muaj melting cov ntsiab lus. Kua- ntim cov tshuaj ntsiav ua kom yooj yim rau kev tsim khoom.
Ibuprofen, guaiacyl ether, oily vitamins, thiab ntau yam khoom noj qab haus huv ua kua, suav nrog pom palmetto roj, taub dag noob roj, linseed roj squalene, qej roj, Ginger roj, thiab lwm yam kua los yog semi-{0}} kua txiv hmab txiv ntoo extracts, tuaj yeem tau txais txiaj ntsig los ntawm cov thev naus laus zis no.
Tsawg- koob tshuaj lossis siab - tshuaj muaj zog
Ob qhov kev sib tw tseem ceeb rau cov tshuaj no yog ua kom tau txais cov ntsiab lus sib xws thiab tswj kev hla -kev sib kis thaum ua kom muaj kev tiv thaiv cov neeg ua haujlwm zoo. Kev ua haujlwm ua kua dej tuaj yeem tswj hwm qhov sib txawv ntawm qhov sib txawv mus rau hauv 1%, yog li ntawd, kua - ntim cov tshuaj ntsiav uas muaj cov tshuaj daws teeb meem tuaj yeem ua kom cov ntsiab lus zoo sib xws rau cov tshuaj tsawg - cov tshuaj xws li vitamin D thiab nws cov khoom siv, diphenoxylate, thiab coenzyme Q10. Lub tshuab ntawm liquefying cov tshuaj hormones thiab tshuaj cytotoxic thiab tom qab ntawd muab tso rau hauv cov kua -cov tshuaj ntsiav tuaj yeem txo cov plua plav paug thiab ua rau cov neeg ua haujlwm raug mob thaum lub sijhawm tsim khoom, ua rau cov txheej txheem ntau lawm.
